|
KMID : 1130620050010020142
|
|
Journal of Clinical Neurology
2005 Volume.1 No. 2 p.142 ~ p.147
|
|
|
Plasma Fibrinolysis Inhibitor Levels in Acute Stroke Patients with Thrombolysis Failure
|
|
Kim Seo-Hyun
Han Sang-Won
Kim Eun-Hee
Kim Dong-Joon
Lee Kyung-Yul
Kim Dong-Ik
Heo Ji-Hoe
|
|
|
Abstract
|
|
|
Background and Purpose: Thrombolytics-induced recanalization fails in a significant portion of patients with ischemic stroke, which is partly due to the resistance of clots to lysis by thrombolytic agents. The pretreatment level of endogenous fibrinolysis inhibitors may affect such thrombolysis failure.
Methods: We studied 43 stroke patients whose arterial recanalization had been evaluated by angiography, and whose blood had been obtained prior to the administration of thrombolytic agents. Plasma samples from 34 healthy volunteers were used as normal controls. Plasminogen activator inhibitor type 1 (PAI-1) and thrombin-activatable fibrinolysis inhibitor (TAFI) levels were quantified using an enzyme-linked immunosorbent assay.
Results: Arteries were recanalized [Thrombolysis in Myocardial Infarction (TIMI) grade 2 or 3] in 30 patients, but not (TIMI grade 0 or 1) in the other 13. The plasma PAI-1 level was significantly higher in patients without recanalization (nonrecanalization) than in those with recanalization and in normal controls. The TAFI levels did not differ among the groups.
Conclusions: The pretreatment PAI-1 levels are increased in acute stroke patients with thrombolysis failure
|
|
|
KEYWORD
|
|
|
Fibrinolytic agents, Acute stroke, Plasminogen activator inhibitor type 1, Thrombin-activatable fibrinolysis inhibitor
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
   
|